Issaquena County was established in the year 1844. The area covered by the county is 441.36 sq mi. More than 1.4K people with an enriched amalgamation of races including White, Native American, black or African American, Asian, Hispanic or Latino, Pacific Islander, and others along with 726 households and 500 family units reside in this region. Mayersville is the county seat and the largest city.

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